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The C677T variant results from a single nucleotide substitution at this position, in which cytosine is replaced by thymine resulting a conversion of alanine to valine residue 24

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The iMyos cells employed by Batista, Haider and colleagues provide an elegant means to profile signalling responses from individuals [32,33], however the increase in glucose uptake stimulated by insulin is far below that observed in skeletal muscle in vivo [120–122], suggesting this model may not recapitulate important aspects of muscle insulin action